Thank you for visiting the website of the Toyooka Lab at Drexel University College of Medicine in Philadelphia.

Our team studies the molecular and cellular mechanisms underlying healthy cortical development. Current research focuses on identifying genes involved in neuronal morphogenesis, including neurite and spine formation and neural connectivity, as well as the etiology of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and 17p13.3 deletion/duplication syndromes.

We have used an array of techniques to achieve this goal. A few examples are in utero electroporation, time-lapse live imaging of culture neurons and on brain slices, mouse genetic approaches including transgenic and knockout mice, GRAPHIC and FingR techniques for studying neural connectivity, as well as calcium imaging.

1/11/2023: Our original article about Adnp and 14-3-3 in brain development has been published in Molecular Psychiatry.

https://rdcu.be/c3ctI

DOI:  10.1038/s41380-022-01939-3

https://pubmed.ncbi.nlm.nih.gov/36631597/