The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling

Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka

Molecular Psychiatry, Published: Jan 11, 2023

KIFC1 regulates the trajectory of neuronal migration.

H. Muralidharan, Shrobona Guha, Kiran Madugula, Ankita Patil, Sarah A. Bennison, Xiaohuan Sun, K. Toyo-oka, P. Baas

Journal of Neuroscience, vol. 42(11), 2022, pp. 2149-2165

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

Megan R. Radler, Xiaonan Liu, Megan Peng, Brenna Doyle, Kazuhito Toyo-Oka, Elias T. Spiliotis

Current Biology, 2022, In Press

Nuak kinase signaling in development and disease of the central nervous system

Sarah A. Bennison, Xiaonan Liu, Kazuhito Toyo-oka

Cellular Signaling, 2022, In Press

Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6.

Sara M. Blazejewski, Sarah A. Bennison, Ngoc T. Ha, Xiaonan Liu, Trevor H. Smith, K. Dougherty, K. Toyo-oka

Cerebral cortex, vol. 32(4), 2022, pp. 770-795

Correction: Liu et al. Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε). Brain Sci. 2022, 12, 56

Xiaonan Liu, Sarah A. Bennison, Lozen Robinson, K. Toyo-oka

Brain Sciences, vol. 12(3), 2022, p. 311

High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching

Sara M. Blazejewski, Sarah A. Bennison, Xiaonan Liu, K. Toyo-oka

Scientific reports, vol. 11(1), 2021, pp. 1-20

TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity.

W. Fu, Wenhuo Hu, Young-Su Yi, A. Hettinghouse, Guodong Sun, Yufei Bi, Wenjun He, Lei Zhang, G. Gao, Jody Liu, K. Toyo-oka, G. Xiao, D. Solit, P. Loke, Chuan-ju Liu

The Journal of clinical investigation, vol. 131(16), 2021

Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε)

Xiaonan Liu, Sarah A Bennison, Lozen Robinson, Kazuhito Toyo-Oka

Brain Sciences, vol. 12(1), 2021, p. 56

Glutathione S-transferase Pi (Gstp) Proteins Regulate Neuritogenesis in the Developing Cerebral Cortex.

Xiaonan Liu, Sara M. Blazejewski, Sarah A. Bennison, K. Toyo-oka

Human molecular genetics, vol. 30(1), 2021, pp. 30-45

14-3-3 shuttles Activity-dependent neuroprotective protein to the cytoplasm to promote appropriate neuronal morphogenesis, cortical connectivity and calcium signaling

Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, K. Toyo-oka

bioRxiv, 2020

Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration

Sarah A. Bennison, Sara M. Blazejewski, Trevor H. Smith, K. Toyo-oka

Cellular and Molecular Life Sciences, vol. 77(8), 2019, pp. 1511-1530

Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3

Sara M. Blazejewski, Sarah A. Bennison, Trevor H. Smith, K. Toyo-oka

Front. Genet., vol. 9, 2018, p. 80

Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14‐3‐3 protein isotypes in brain

Yue Deng, Beichen Jiang, Carolyn L Rankin, K. Toyo-oka, M. Richter, J. Maupin-Furlow, J. Moskovitz

Free radical biology & medicine, vol. 129, 2018, pp. 600-607

14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis

Brett Cornell, K. Toyo-oka

Front. Mol. Neurosci., vol. 10, 2017, p. 318

Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors

T. Wachi, Brett Cornell, K. Toyo-oka

Behavioural Brain Research, vol. 319, 2017, pp. 31-36

Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects

Brett Cornell, K. Toyo-oka

BMC Research Notes, vol. 9(1), 2016, pp. 1-6

Overexpression of the 14-3-3gamma protein in embryonic mice results in neuronal migration delay in the developing cerebral cortex

Brett Cornell, T. Wachi, V. Zhukarev, K. Toyo-oka

Neuroscience Letters, vol. 628, 2016, pp. 40-46

Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin.

Brett Cornell, T. Wachi, V. Zhukarev, K. Toyo-oka

Human molecular genetics, vol. 25(10), 2016, pp. 4405-4418

Ablation of the 14‐3‐3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex

T. Wachi, Brett Cornell, C. Marshall, V. Zhukarev, P. Baas, K. Toyo-oka

Developmental neurobiology, vol. 76(6), 2016, pp. 600-614

Novel Functions of 14-3-3 Proteins in Neurogenesis and Neuronal Differentiation In Vivo

T. Wachi, K. Toyo-oka

2015

14-3-3ε and ζ Regulate Neurogenesis and Differentiation of Neuronal Progenitor Cells in the Developing Brain

K. Toyo-oka, T. Wachi, Robert F Hunt, S. Baraban, S. Taya, H. Ramshaw, K. Kaibuchi, Q. Schwarz, Angel F. Lopez, A. Wynshaw-Boris

The Journal of Neuroscience, vol. 34(36), 2014, pp. 12168-12181

14-3-3ε Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell Cycle

Y. Kosaka, K. Cieslik, Ling Li, G. Lezin, C. Maguire, Y. Saijoh, K. Toyo-oka, M. Gambello, M. Vatta, A. Wynshaw-Boris, A. Baldini, H. Yost, Luca Brunelli

Molecular and Cellular Biology, vol. 32(24), 2012, pp. 5089-5102

Neuroepithelial Stem Cell Proliferation Requires LIS1 for Precise Spindle Orientation and Symmetric Division

J. Yingling, Y. Youn, D. Darling, K. Toyo-oka, T. Pramparo, S. Hirotsune, A. Wynshaw-Boris

Cell, vol. 132(3), 2008, pp. 474-486

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

K. Toyo-oka, D. Mori, Y. Yano, M. Shiota, H. Iwao, H. Goto, M. Inagaki, N. Hiraiwa, M. Muramatsu, A. Wynshaw-Boris, A. Yoshiki, S. Hirotsune

The Journal of cell biology, vol. 180(6), 2008, pp. 1133-1147

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.

M. Ikeda, T. Hikita, S. Taya, Junko Uraguchi-Asaki, K. Toyo-oka, A. Wynshaw-Boris, H. Ujike, T. Inada, K. Takao, T. Miyakawa, N. Ozaki, K. Kaibuchi, N. Iwata

Human molecular genetics, vol. 17(20), 2008, pp. 3212-3222

NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment

D. Mori, Y. Yano, K. Toyo-oka, Noriyuki Yoshida, Masami Yamada, M. Muramatsu, Dongwei Zhang, H. Saya, Y. Toyoshima, K. Kinoshita, A. Wynshaw-Boris, S. Hirotsune

Molecular and Cellular Biology, vol. 27(1), 2006, pp. 352-367

Erratum: Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of Myc overexpression (Cancer Research (June 1, 2006) 66 (5565-5573))

K. Toyo-oka, T. J. Bowen, S. Hirotsune, Zirong Li, Sonia Jain, S. Ota, L. Escoubet-Lozach, Ivan Garcia-Bassets, J. Lozach, M. Rosenfeld, C. Glass, R. Eisenman, Bing Ren, P. Hurlin, A. Wynshaw-Boris

2006

Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression.

K. Toyo-oka, T. J. Bowen, S. Hirotsune, Zirong Li, Sonia Jain, S. Ota, L. Escoubet-Lozach, Ivan Garcia-Bassets, J. Lozach, M. Rosenfeld, C. Glass, R. Eisenman, Bing Ren, P. Hurlin, A. Wynshaw-Boris

Cancer research, vol. 66(11), 2006, pp. 5565-5573

Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.

K. Toyo-oka, Shinji Sasaki, Y. Yano, D. Mori, Takuya Kobayashi, Y. Toyoshima, Suzumi M. Tokuoka, S. Ishii, Takao Shimizu, M. Muramatsu, N. Hiraiwa, A. Yoshiki, A. Wynshaw-Boris, S. Hirotsune

Human molecular genetics, vol. 14(21), 2005, pp. 3113-3128

Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality

Shinji Sasaki, D. Mori, K. Toyo-oka, Amy Chen, L. Garrett-Beal, M. Muramatsu, S. Miyagawa, N. Hiraiwa, A. Yoshiki, A. Wynshaw-Boris, S. Hirotsune

Molecular and Cellular Biology, vol. 25(17), 2005, pp. 7812-7827

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.

K. Toyo-oka, S. Hirotsune, M. Gambello, Zi-Qiang Zhou, Lorin E. Olson, M. Rosenfeld, R. Eisenman, P. Hurlin, A. Wynshaw-Boris

Human molecular genetics, vol. 13(10), 2004, pp. 1057-1067

Evidence of Mnt-Myc Antagonism Revealed by Mnt Gene Deletion

P. Hurlin, Zi-Qiang Zhou, K. Toyo-oka, S. Ota, William L Walker, S. Hirotsune, A. Wynshaw-Boris

Cell cycle, vol. 3(2), 2004, pp. 95-97

Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.

C. Cardoso, R. Leventer, Heather L Ward, K. Toyo-oka, June Chung, A. Gross, C. Martin, J. Allanson, D. Pilz, A. Olney, O. Mutchinick, S. Hirotsune, A. Wynshaw-Boris, W. Dobyns, D. Ledbetter

American journal of human genetics, vol. 72(4), 2003, pp. 918-930

Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse.

J. Yingling, K. Toyo-oka, A. Wynshaw-Boris

American journal of human genetics, vol. 73(3), 2003, pp. 475-488

14-3-3ε is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller–Dieker syndrome

K. Toyo-oka, Aki Shionoya, M. Gambello, C. Cardoso, R. Leventer, Heather L Ward, Ramsés Ayala, L. Tsai, W. Dobyns, D. Ledbetter, S. Hirotsune, A. Wynshaw-Boris

Nature Genetics, vol. 34(3), 2003, pp. 274-285

Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

P. Hurlin, Zi-Qiang Zhou, K. Toyo-oka, S. Ota, William L Walker, S. Hirotsune, A. Wynshaw-Boris

The EMBO journal, vol. 22(18), 2003, pp. 4584-4596

Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line

C. Park, Yi-fu Yang, Xuyu Zhou, K. Toyo-oka, Y. Yashiro‐Ohtani, W. Park, M. Tomura, X. Tai, T. Hamaoka, H. Fujiwara

2002

Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line.

C. Park, Yi-fu Yang, Xuyu Zhou, K. Toyooka, Y. Yashiro‐Ohtani, W. Park, M. Tomura, X. Tai, T. Hamaoka, H. Fujiwara

International immunology, 2002

Functional annotation of a full-length mouse cDNA collection

J. Kawai, A. Shinagawa, K. Shibata, M. Yoshino, M. Itoh, Y. Ishii, T. Arakawa, A. Hara, Y. Fukunishi, H. Konno, J. Adachi, S. Fukuda, K. Aizawa, M. Izawa, K. Nishi, H. Kiyosawa, S. Kondo, I. Yamanaka, T. Saito, Y. Okazaki, T. Gojobori, H. Bono, T. Kasukawa, R. Saito, K. Kadota, H. Matsuda, M. Ashburner, S. Batalov, T. Casavant, W. Fleischmann, T. Gaasterland, C. Gissi, B. King, H. Kochiwa, P. Kuehl, S. Lewis, Y. Matsuo, I. Nikaido, G. Pesole, John Quackenbush, L. Schriml, F. Staubli, R. Suzuki, M. Tomita, L. Wagner, T. Washio, K. Sakai, T. Okido, M. Furuno, H. Aono, R. Baldarelli, G. Barsh, J. Blake, D. Boffelli, N. Bojunga, Piero Carninci, M. Bonaldo, M. Brownstein, C. Bult, C. Fletcher, M. Fujita, M. Gariboldi, S. Gustincich, D. Hill, M. Hofmann, D. Hume, M. Kamiya, N. Lee, P. Lyons, L. Marchionni, J. Mashima, J. Mazzarelli, P. Mombaerts, P. Nordone, B. Ring, M. Ringwald, I. Rodriguez, N. Sakamoto, H. Sasaki, K. Sato, C. Schönbach, T. Seya, Y. Shibata, Kai-Florian Storch, H. Suzuki, K. Toyo-oka, K. H. Wang, C. Weitz, C. Whittaker, L. Wilming, A. Wynshaw-Boris, K. Yoshida, Y. Hasegawa, H. Kawaji, S. Kohtsuki, Y. Hayashizaki

Nature, vol. 409(6821), 2001, pp. 685-690

TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

S. Merscher, B. Funke, J. Epstein, J. Heyer, A. Puech, M. Lu, R. Xavier, M. Demay, R. Russell, S. Factor, Kazuhito Tokooya, B. S. Jore, M. Lopez, R. Pandita, M. Lia, D. Carrión, Hui Xu, H. Schorle, J. Kobler, P. Scambler, A. Wynshaw-Boris, A. Skoultchi, B. Morrow, R. Kucherlapati

Cell, vol. 104(4), 2001, pp. 619-629

CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4+CD8+ Thymocytes and Supports Their Differentiation to the CD4 Lineage1

Xuyu Zhou, Y. Yashiro‐Ohtani, K. Toyo-oka, C. Park, X. Tai, T. Hamaoka, H. Fujiwara

The Journal of Immunology, 2000

Rafts by Enhancing the Association of TCR with in T Cell Rafts Induce T Cell Costimulation Non-CD28 Costimulatory Molecules Present

Y. Yashiro‐Ohtani, Xuyu Zhou, K. Toyo-oka, X. Tai, C. Park, T. Hamaoka, R. Abe, K. Miyake, H. Fujiwara

2000

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts1

Y. Yashiro‐Ohtani, Xuyu Zhou, K. Toyo-oka, X. Tai, C. Park, T. Hamaoka, R. Abe, K. Miyake, H. Fujiwara

The Journal of Immunology, 2000

Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association.

K. Toyo-oka, Y. Yashiro‐Ohtani, C. S. Park, X. Tai, K. Miyake, T. Hamaoka, H. Fujiwara

International immunology, 1999

TCR-Restimulated , Activated T Cells TCR / CD 9-Costimulated , Naive T Cells and Protease Pathway in Apoptosis of Differential Involvement of a Fas-CPP 32-Like

C. Park, Y. Yashiro, X. Tai, K. Toyo-oka, T. Hamaoka, H. Yagita, K. Okumura, S. Neben, H. Fujiwara

1998

Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells.

C. S. Park, Y. Yashiro, X. Tai, K. Toyo-oka, T. Hamaoka, H. Yagita, K. Okumura, S. Neben, H. Fujiwara

Journal of immunology, 1998

A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture.

K. Toyooka, X. Tai, C. S. Park, Y. Yashiro, T. Hamaoka, H. Fujiwara

Immunology letters, 1998

A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co‐stimulatory molecules

Y. Yashiro, X. Tai, K. Toyo-oka, C. S. Park, R. Abe, T. Hamaoka, M. Kobayashi, S. Neben, H. Fujiwara

European journal of immunology, 1998

Synergy between CD28 and CD9 costimulation for naive T-cell activation.

K. Toyo-oka, X. Tai, Y. Yashiro, H. Ahn, R. Abe, T. Hamaoka, M. Kobayashi, S. Neben, H. Fujiwara

Immunology letters, 1997

Suppression of allograft responses induced by interleukin-6, which selectively modulates interferon-gamma but not interleukin-2 production.

M. Tomura, I. Nakatani, M. Murachi, X. Tai, K. Toyo-oka, H. Fujiwara

Transplantation, 1997

Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes.

X. Tai, K. Toyo-oka, N. Yamamoto, Y. Yashiro, J. Mu, T. Hamaoka, H. Fujiwara

Journal of immunology, 1997

CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis.

X. Tai, K. Toyooka, Y. Yashiro, R. Abe, C. S. Park, T. Hamaoka, M. Kobayashi, S. Neben, H. Fujiwara

Journal of immunology, 1997

CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism.

K. Toyooka, S. Maruo, T. Iwahori, N. Yamamoto, X. Tai, R. Abe, Y. Takahama, M. Murakami, T. Uede, T. Hamaoka, H. Fujiwara

International immunology, 1996

IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.

S. Maruo, K. Toyo-oka, M. Oh‐hora, X. Tai, H. Iwata, H. Takenaka, S. Yamada, S. Ono, T. Hamaoka, M. Kobayashi, M. Wysocka, G. Trinchieri, H. Fujiwara

Journal of immunology, 1996

CD28 co-stimulatory signals induced IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2- independent mechanism.

Toyooka Kazuhito, Maruo Seiji, Iwahori Tohru, Yamamoto Norihiko, Tai Xu-Guang, Abe Ryo, Takahama Yousuke, Murakami Masaaki, Uede Toshimitsu, Hamaoka Toshiyuki, Fujiwara Hiromi

1996

A role for CD9 molecules in T cell activation

X. Tai, Y. Yashiro, R. Abe, K. Toyooka, C. Wood, J. Morris, A. Long, S. Ono, M. Kobayashi, T. Hamaoka, S. Neben, H. Fujiwara

The Journal of experimental medicine, 1996

Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin.

H. Iwata, T. Nagano, K. Toyo-oka, H. Hirose, T. Hamaoka, H. Fujiwara

Transplantation proceedings, 1994

Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin.

H. Iwata, T. Nagano, K. Toyo-oka, H. Hirose, T. Hamaoka, H. Fujiwara

International immunology, 1994

Thymic stroma-derived T-cell inhibitory factor (TSTIF). 2: TSTIF acts on the antigen-presenting cell to inhibit antigen-stimulated T-cell proliferation.

X. Tai, Y. Kita, K. Toyooka, T. Hamaoka, H. Fujiwara

Thymus, 1993